SrasV1, France, Analysis, bibRecord, 000230

Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

Identifieur interne : 000230 ( France/Analysis ); précédent : 000229; suivant : 000231

Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

Auteurs : YONGJIN WANG [République populaire de Chine] ; HUILING SHI [République populaire de Chine] ; Pascal Rigolet [France] ; NANNAN WU [République populaire de Chine] ; LICHEN ZHU [République populaire de Chine] ; Xu-Guang Xi [France] ; Astrid Vabret [France] ; XIAOMING WANG [République populaire de Chine] ; TIANHOU WANG [République populaire de Chine]

Source :

Infection, genetics and evolution : (Print) [ 1567-1348 ] ; 2010.

RBID : Pascal:10-0456478

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Protéine, Immunité, Coronavirus, Epidémiologie moléculaire.

English descriptors

KwdEn :
- Coronavirus, Immunity, Molecular epidemiology, Protein, Severe acute respiratory syndrome.

Abstract

The nsp1 protein of the highly pathogenic SARS coronavirus suppresses host protein synthesis, including genes involved in the innate immune system. A bioinformatic analysis revealed that the nsp1 proteins of group 1 and SARS coronaviruses have similar structures. Nsp1 proteins of group I coronaviruses interacted with host ribosomal 40S subunit and did not inhibit IRF-3 activation. However, synthesis of host immune and non-immune proteins was inhibited by nsp1 proteins at both transcriptional and translational levels, similar to SARS coronavirus nsp1. These results indicate that different coronaviruses might employ the same nsp1 mechanism to antagonize host innate immunity and cell proliferation. However, nsp1 may not be the key determinant of viral pathogenicity, or the factor used by the SARS coronavirus to evade host innate immunity.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000136
to stream PascalFrancis, to step Curation: 000852
to stream PascalFrancis, to step Checkpoint: 000138
to stream Main, to step Merge: 002970
to stream Main, to step Curation: 002929
to stream Main, to step Exploration: 002929
to stream France, to step Extraction: 000230

Links to Exploration step

Pascal:10-0456478

Le document en format XML

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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Wildlife Epidemic Diseases, East China Normal University</s1>
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<front><div type="abstract" xml:lang="en">The nsp1 protein of the highly pathogenic SARS coronavirus suppresses host protein synthesis, including genes involved in the innate immune system. A bioinformatic analysis revealed that the nsp1 proteins of group 1 and SARS coronaviruses have similar structures. Nsp1 proteins of group I coronaviruses interacted with host ribosomal 40S subunit and did not inhibit IRF-3 activation. However, synthesis of host immune and non-immune proteins was inhibited by nsp1 proteins at both transcriptional and translational levels, similar to SARS coronavirus nsp1. These results indicate that different coronaviruses might employ the same nsp1 mechanism to antagonize host innate immunity and cell proliferation. However, nsp1 may not be the key determinant of viral pathogenicity, or the factor used by the SARS coronavirus to evade host innate immunity.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>République populaire de Chine</li>
</country>
<region><li>Basse-Normandie</li>
<li>Région Normandie</li>
<li>Île-de-France</li>
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<name sortKey="Huiling Shi" sort="Huiling Shi" uniqKey="Huiling Shi" last="Huiling Shi">HUILING SHI</name>
<name sortKey="Lichen Zhu" sort="Lichen Zhu" uniqKey="Lichen Zhu" last="Lichen Zhu">LICHEN ZHU</name>
<name sortKey="Nannan Wu" sort="Nannan Wu" uniqKey="Nannan Wu" last="Nannan Wu">NANNAN WU</name>
<name sortKey="Tianhou Wang" sort="Tianhou Wang" uniqKey="Tianhou Wang" last="Tianhou Wang">TIANHOU WANG</name>
<name sortKey="Xiaoming Wang" sort="Xiaoming Wang" uniqKey="Xiaoming Wang" last="Xiaoming Wang">XIAOMING WANG</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Rigolet, Pascal" sort="Rigolet, Pascal" uniqKey="Rigolet P" first="Pascal" last="Rigolet">Pascal Rigolet</name>
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<name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name>
<name sortKey="Xi, Xu Guang" sort="Xi, Xu Guang" uniqKey="Xi X" first="Xu-Guang" last="Xi">Xu-Guang Xi</name>
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Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri